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Yes, switching between compounds is a standard practice when one medication causes intolerable side effects

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This not only simplifies the process but also keeps everything more consistent, which is important when dealing with multiple components

Therefore, we challenged mice with hepatic-specific PGC-1 overexpression on a chow diet with a subtoxic dose of APAP and we found that PGC-1 overexpression renders the liver more sensitive to APAP damage, mainly due to intense oxidative stress, finally ending up with liver necrosis and mice death