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The dynamic interactions between B-ALL blasts and niche cells (vascular ECs, perivascular mesenchymal stem cells, and osteoblasts) were studied, identifying specific roles of these cells in regulating cytokines, adhesive signaling, and downstream B-ALL survival pathways, as well as markers of proliferation and quiescence, highlighting a subtype-related heterogeneity and responses to treatment

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Availability of data and materials The RNA-sequencing data has been uploaded to NCBI's Gene Expression Omnibus (GEO) and can be accessed by public ( All data generated or analyzed in this study are included in this article

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