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Recently, to ensure the safety of GLP-1 RA on sarcopenia, a clinical randomized multicenter trial of bimagrumab, an antibody blockade of activin type II receptor inhibitor, alone or in addition to subcutaneous semaglutide is now ongoing (NCT05616013) [113]

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These FDCs have been approved as an adjunct to diet and exercise to improve glycemic control in adults with T2DM when treatment with both an SGLT2i and DPP4i is appropriate (Table 1)