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Caffeine Sensitivity: It moderates the central nervous system effects of caffeine, helping to reduce the jitters and heart rate spikes that often accompany caffeine consumption in dysautonomia patients

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In the questionnaires, the following features/items were addressed: skin lightening, facial skin evenness, pigmented spots lightening, pore size improvement, skin smoothness, wrinkle reduction crows feet, wrinkle reduction nasolabial folds, wrinkle reduction forehead, general skin condition, fatigability, sleep (e.g., quality and length) Safety To evaluate the safety of subjects, vital signs were determined at each visit

Group one included patients with moderate PAD who were started on GLP-1 RAs, and group two included patients with moderate PAD who were not started on GLP-1 RAs