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Cardiometabolic Improvements Weight loss was accompanied by clinically meaningful improvements across several cardiovascular risk markers, including reductions in: Waist circumference (mean reduction of approximately 24.1 cm at the highest dose) Non-HDL cholesterol Triglycerides Systolic blood pressure High-sensitivity C-reactive protein (hsCRP) a marker of inflammation These findings are particularly relevant for patients with obesity who also live with cardiometabolic conditions, where systemic risk reduction is as important as the weight loss itself

484 This necessitates the development of innovative therapeutic strategies that specifically target CSCs while minimizing off-target effects on NSCs

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Thyroid Tumors Studies raise concerns about thyroid cancer, which regulators are continuing to review