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These large, complex molecules are inherently unstable and prone to degradation through pathways such as aggregation, deamidation, and oxidation 3

In addition to the Fe-S cluster, heme is an essential iron-containing compounds in the body, serving as a cofactor in the formation of key proteins such as hemoglobin, myoglobin, and cytochrome C, and is highly conserved, similar to the Fe-S cluster [82]

The NHS recommends testing if persistent symptoms suggest deficiency, since early treatment can reverse most problemsnhs.uk