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Indeed, insulin regulates renal gluconeogenesis by influencing enzyme production or activity associated with the availability of gluconeogenic precursors (Cano, 2001), an influence anticipated to be diminished or impaired in individuals with MetS or obesity-related insulin resistance (Rebelos et al., 2024)

Emerging studies are exploring whether GLP-1s could also help slow the progression of kidney disease, though current findings are still preliminary

For our clinical overview of how this works in practice, see our complete guide to Tesamorelin and its documented effect on abdominal fat reduction in South Florida patients

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