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Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: modulation of histone deacetylase activity

Valverde-Lpez F, Martnez-Cara JG, Redondo-Cerezo E

Because GPX4 is the major PLOOH-neutralizing enzyme, one of the usual molecular mechanisms of erastin and RSL-3-induced ferroptosis is that both compounds inhibit GPX4 activity, except that erastin does so directly, whereas RSL-3 inhibits GPX4 activity by inhibiting cysteine uptake (Shintoku et al., 2017)