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However, systemically injected labeled GLP1RAs show limited brain penetration, with the strongest labeling observed in circumventricular organs such as the AP and arcuate nucleus (ARC), suggesting that most central effects are mediated by downstream signaling from these primary GLP1RA binding sites 14

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Autoimmune conditions aren't treated but the conditions caused are ie Graves hyperthyroidism is treated with Carbimazole, and Hashimoto's (without Graves) causes hypothyroidism which is treated with Levothyroxine