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We also know it extends beyond excruciating pain, to light sensitivity and nausea

It also works on the hypothalamus which is responsible for regulating appetite and satiety ultimately leading to decreased feeling of hunger and cravings while also promoting a feeling of fullness

The MASH mouse and hamster work published by Briand and colleagues in 2026 showed dose-dependent reductions in body weight, hepatic steatosis, and liver enzymes that exceeded what dual agonists produced in the same models (Briand et al., Obesity, 2026)

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