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Also, MSCs-EVs (from BM) release miR-378a-3p, which blocks GATA-binding protein 2 (GATA2), downregulating aquaporin-4 (AQP4) expression, and disrupting the peroxisome proliferator-activated receptor- (PPAR-) signaling pathway

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While dysplastic naevi are potential melanoma precursors, few will actually evolve into melanomas, but their presence defines a population at higher risk for developing melanoma