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Weve now witnessed a remarkable paradigm shift, driven by our new understanding that appetite and satiety are regulated hormonally, not just behaviorally, and that the gut-brain axis plays a central role in maintaining energy balance

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Moreover, while our MR analysis found no genetic evidence supporting a causal protective effect of metformin or semaglutide on AD, this does not rule out non-genetic mechanisms, such as metformins antiviral properties or microbiota modulation, which are not captured by MR analysis