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doi: 10.1111/jth.14234 88 ZhuWGregoryJCOrgEBuffaJAGuptaNWangZet al

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[29], based on a Danish population-based study, found that using metformin combined with a dipeptidyl peptidase 4 inhibitor (DPP-4I) as a baseline control, this treatment regimen was observed to be associated with an increased risk of DR in the group of GLP-1RA (Exenatide, Liraglutide, Lixisenatide, Dulaglutide) combined with metformin, but relative to the metformin combined with insulin group, this regimen had a lower risk of DR but still higher than that of the metformin combined with DPP-4I group and the sodium-glucose cotransporter protein-2 inhibitor (SGLT-2I) group