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doi: 10.3390/nu9070659 86

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Combined use demonstrates improved outcomes in animal research, including: Faster formation of granulation tissue and wound closure Reduced edema and inflammation Enhanced tendon-to-bone integration and ligament tensile strength Systemic protection of organs such as liver and kidney in ischemia-reperfusion models Systematic reviews of over 35 preclinical studies consistently report positive histological and functional results, with no observed toxicity

Indirect tests involve oral administration of test substances, followed by measurement of their concentration in blood or urine