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It should be emphasized that in our experimental model, based on the inoculation of melanoma cells directly into the bloodstream, the cells could start to divide once they reached a suitable niche such as a metastatic site

These Bregs secrete cytokines including IL-10 to suppress the function of Th1 and Th17 cells, reduce the levels of inflammatory cytokines secreted by DCs, and promote the differentiation of Forkhead Box P3 (Foxp3 + ) Tregs (71, 72)