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Retatrutide (RETA) is a next-generation peptide being researched for its multi-pathway activity, targeting key receptors involved in appetite regulation, energy balance, and glucose metabolism

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64,65,66 As a transcriptional factor, SOX10 activates various targets like MITF, long non-coding RNA (lncRNA) SAMMSON, forkhead box D3 (FOXD3), and RAB7 to regulate cell proliferation, mitochondrial function, and endolysosomal pathway, therefore affecting various biological activities in melanoma 67,68,69,70 (Fig

Strategies for the management of weight in patients with type 2 diabetes include lifestyle modifications, pharmacotherapy and surgery