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doi: 10.1210/jc.2003-031868 33 American DiabetesA

Stress, aging, and environmental toxin exposure can all lower glutathione levels

These include direct effects on GLP-1R + cells within joints, the heart, kidney, liver, and immune cells 14 and indirect actions through weight reduction and blood glucose control, as well as through interorgan communication to dampen inflammation via activation of GLP-1R in subsets of central nervous system neurons 15 (Figure 1B)