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The major subclasses of flavonoids including flavones, anthocyanidins, isoflavones, chalcones, dihydroflavones, dihydroflavonols and flavanols and their effects in liver disease are reviewed separately

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In a randomized controlled trial of 72 patients with type 2 diabetes and reduced heart rate variability, oral supplementation with 800 mg/day of lipoic acid for four months resulted in significant improvement in two out of four measures of heart rate variability compared to placebo (81)

OTC products often contain lower or variable doses and are not tailored to deficiency treatment