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4 The hypothesized mechanism of gut microbiome dysbiosis in NIU 4.1 Increased intestinal permeability and gut microbial translocation Alterations in the gut microbiome may affect intestinal permeability and lead to leaky gut, which would allow the translocation of gut microbes and their products into the systemic circulation, thereby triggering innate and/or adaptive immune responses

Ufnalska I, Drew SC, Zhukov I, Szutkowski K, Wawrzyniak UE, Wroblewski W, et al