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Maintenance dosing is typically appropriate when a patient has reached targeted clinical or individual weight loss goals and approached a plateau point where there is no active weight loss or weight regain, says Gitanjali Srivastava, MD, medical director of Vanderbilt Obesity Medicine

The expansion of Tregs via IL-2/IL-2 antibody complexes and brain-targeted IL-2 overexpression in astrocytes via AAV vectors have shown beneficial effects in MCAO and cortical impact mouse models of stroke [342, 343]

Lima LT, Nunes DPT, Gomes GW, Chauffaille MdeLLF, Silva MRR, Ponce CC, et al

For the researchers, this finding raised questions about implications for aging, frailty and fitness in the long term