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Last September, Jenn Rossum hit a wall

Willoughby-Drupe is shown interviewing the old Scotsman in the pub while both are seen in the crowd of reporters welcoming Tintin at the docks (page 61)

Overall, these findings indicate that targeting both GIPR and GLP-1R in the CNS with peptideantibody conjugates, enabling GIPR blockade together with GLP-1R agonism, enhances weight loss

Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Baar et al., 2017)