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Patients should be counselled about realistic expectations, potential side effects, and the importance of continued thyroid monitoring throughout treatment

GLP-1R Trp 78 , Pro 90 , Trp 91 , and His 212 could form a hydrophobic region with GLP-1 Phe 28 , Ile 29 , Trp 31 , Leu 32 , and Val 33 , and GIPR Leu 35 , Trp 39 , Tyr 36 , Met 67 , Tyr 87 , Trp 90 , and His 115 could form a hydrophobic region with GIP Phe 22 , Val 23 , Trp 25 , Leu 26 , and Leu 27

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These results indicate a dose-dependent response where the body adjusts gradually over a structured titration schedule, typically expressed in mg per week