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Prader Willi syndrome: genetics, metabolomics, hormonal function, and new approaches to therapy

In the intestine, we detected the protein levels of PC1/3 and PKA by Western blot (Figure 4G), and found that the expression of PC1/3 and the phosphorylation level of PKA increased after the treatment of berberine (Figures 4H, I)

In preclinical models, it increases insulin release and decreases glucagon, which is the activation of GLP-1 receptors