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This article discusses the potential causes of black stools, when one needs to be concerned, and what steps can be taken to solve the issue

doi: 10.1016/j.fct.2019.05.048 150 MaM-LMaZ-JHeY-LSunHYangBRuanB-Jet al

Mechanistically, autocrine IGF-2 promotes self-activation by binding to the IGF-1 receptor (IGF-1R) on CAFs and activating PI3K/AKT signaling, followed by the secretion of various chemokines and cytokines (CCL5 and CXCL12) by CAFs to influence the infiltration of T cell

A high GSH concentration and a reduced cellular state are known to promote self-renewal, allowing the GSH-to-ROS ratio to be a key determinant of cell fate (Zhou et al., 2016)