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While this has not been observed in humans, it remains a theoretical risk, and patients with a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) are typically advised against using Semaglutide

By the six-month mark, the majority have either no side effects or mild, manageable symptoms that do not significantly impact quality of life

Semaglutide should be injected under the skin (this is called subcutaneous injection) in the stomach area (abdomen), upper leg (thigh), or upper arm as instructed by your healthcare provider

Activation of these receptors may influence the balance between sympathetic (stimulatory) and parasympathetic (inhibitory) nervous system activity