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Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression

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That same logic appears to extend to drugs of abuse

an HMGCR-independent pathway, including allosteric hindrance of lymphocyte function-associated antigen 1 (LFA-1), which represses activation, proliferation, and cellular migration of T cells [40] and HMGCR-dependent mechanisms, which rely on their ability to prevent prenylation of small GTPases [41, 42]