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The Bottom Line TRIUMPH-4 establishes retatrutide as the most potent pharmacological weight loss agent ever tested in a Phase III program

The results of a trial of semaglutide in obese patients with HFpEF showed a significant amelioration of symptoms and improvements in motor function and weight loss compared with patients treated with a placebo.470 In this study, researchers randomized 529 patients with heart failure with a preserved ejection fraction and body mass index (weight in kilograms in the square of the height in meters) 30 to receive once-weekly injections of semaglutide (2.4 mg) or placebo for 52 weeks

However, clinicians should remain informed as the field evolves

10.1186/s13287-022-03218-y 9 AndrS