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However, there are significant gaps in our understanding, including determining optimal dosages for efficacy and safety, elucidating precise mechanisms of action, establishing clinical efficacy through more large-scale trials, developing personalized treatment approaches, and studying the longstanding effects of vitamin supplementation in cancer patients

Post-trial follow-up data from EMPA-KIDNEY suggest that cardiorenal benefits may persisted for up to 1 year after treatment cessation, highlighting the importance of continued therapy for long-term effectiveness [117]

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