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310 In an in vivo diabetic cardiomyopathy model, pifithrin- impaired angiogenesis, restored cellular senescence, and decreased glycolysis by suppressing the transcription of p53-dependent target genes, including HIF-1, p16, p21, p16, glucose transporter 1 (GLUT-1), and glucose transporter 4 (GLUT-4)

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Looking aheadCV benefits expansion A supplemental new drug application (sNDA) is under review to broaden Rybelsuss indication to include major adverse cardiovascular events risk reduction in type 2 diabetes patients with cardiovascular or kidney disease