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Diabetic Intervention with Vitamins to Improve Nephropathy (DIVINe) was a double blind RCT on a population of 238 patients with diabetic kidney disease randomized to receive 2.5 mg folic acid plus 25 mg vitamin B6 plus 1 mg vitamin B12, or placebo (mean eGFR was 64 mL/min in treatment group and 58 mL/min in the placebo group)

Tesamorelin is approved as a therapy for patients with HIV whove accumulated excess abdominal fat, but its also prescribed off-label to people seeking reductions in their visceral adiposity, increases in their muscle mass, and improvements in their cardiovascular or cognitive health

Aqua (water), Propanediol, Butylene Glycol, Glycerin, Caffeine, Biotinoyl Tripeptide-1, Acetyl Tetrapeptide-3, Larix Europaea Wood Extract, Pisum Sativum Extract, Scutellaria Baicalensis Root Extract, Triticum Vulgare Germ Extract, Glycine Soja Germ Extract, Trifolium Pratense Flower Extract, Camellia Sinensis Leaf Extract, Apigenin, Oleanolic Acid, Arginine, Glycine, Calcium Gluconate, Zinc Chloride, Lactic Acid, Gluconolactone, Dextran, Maltodextrin, Hydroxyethylcellulose, Xanthan Gum, Pentylene Glycol, Dimethyl Isosorbide, Polysorbate 20, PPG-26-buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Sodium Metabisulfite, Sodium Benzoate, Phenoxyethanol, Chlorphenesin

Journal of Physiology-Paris, 97(1), 15-25