GLP-1R mRNA and GLP-1 immunoreactivity was detected in the VTA and NAc, as well as other reward associated areas including lateral hypothalamus, lateral habenula, hippocampus, and substantia nigra (Merchenthaler et al., Afferent and efferent innervation of the hindbrain GLP-1-producing neurons Unlike many of its gut or fat hormone counterparts (ghrelin or leptin) for which there is little evidence of central production, GLP-1 can be made in the brain
Bogunovic M, Dav SH, Tilstra JS, Chang DT, Harpaz N, Xiong H, et al
It is reasonable to expect that similar dynamics could apply with retatrutide, meaning that one participant may require a higher dose to achieve the same outcomes as another
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