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When taken in pill form, it can be quickly broken down in the digestive tract before it reaches the cells, reducing its effectiveness
Continuous, non-pulsatile GH elevation is actually a problem: sustained receptor activation leads to desensitization and blunted response
Journal of Cosmetic Dermatology, June 2019, pages 728-737 4
However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007
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