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This has triggered the evolution of resistance mechanisms whereby the water-soluble toxic form of mercury, the Hg 2+ cation (either aquated or coordinated to ligands such as chloride), is reduced back to the mono-atomic elemental form, the atoms of which are volatile and can be eliminated from the organism back into the environment [87]

The chondral defect (4 mm in diameter) was created in the trochlear groove of the distal femur according to a previously described method [24]

In the context of mitohormesis, growing evidence suggests that an evolutionary hunter-gatherer dietary lifestyle aimed at balancing (1) minimally-processed, carbohydrate-restricted feeding periods (challenging, not excessive, stressor phases) with (2) intermittent fasting protocols (complete, not excessive, recovery phases) should be considered as a preventative and therapeutic strategy for neurodegenerative disorders