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PROTO1 provides robust protection against kanamycin-induced hearing loss in rats, in Proceedings of the Association for Research in Otolaryngology Annual Meeting (Baltimore, MD)

Side effects tend to be dose-dependent and include nausea, vomiting, abdominal cramps, diarrhea, and a fishy body odor

This is in accordance with previous findings that an increase in MDA level due to lipid peroxidation is one of the most common markers of cellular oxidative damage under the heat stress 40