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It occurs more commonly in people who have other autoimmune diseases such as thyroid diseases, Addisons disease and vitiligo

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2.Anterior cruciate ligament injury-ACL Predispositions related to the occurrence of anterior cruciate ligament injury-ACL may not only be the primary cause, which is considered to be the mechanism of anterior cruciate ligament injury with simultaneous knee rotation or rotation on a straight knee, but also insufficiency of the gluteus medius muscle or the age of the person engaging in physical activity

On the other hand VEGF is researched for its role in angiogenesis, the formation of new blood vessels from pre-existing vessels