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A thorough review of the full manuscripts of relevant articles, including the title, abstract, and conclusion, has been conducted to ensure that they meet the expediency criterion (Figure 1)

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serdexmethylphenidate/ dexmethylphenidate methylphenidate hydrochloride Aptensio XR Concerta methamphetamine hydrochloride Contempla XR ODT Daytrana patch Within an hour Within 2 hours First peak effect 1.5 hours Second peak effect 6.5 Jornay PM Metadate CD Metadate ER Methylin ER Quillichew ER Ritalin-SR Ritalin LA 8 to 10 hours First 4 hours about 2 hours about 45 minutes 22 to 24 hours (10 to 12 hours after delayed onset) Up to 12 hours 8 hours 8 hours Up to 8 hours 8 hours 8 hours dextroamphetamine sulfate dextroamphetamine sulfate (oral solution) Dexedrine Spansule Dexedrine ProCentra 30 minutes Immediate Immediate 6 to 9 hours 4 to 6 hours Vyvanse chewable Vyvanse Nonstimulant ADHD Medication While stimulants are effective for some people with ADHD, they have one major drawback: They are controlled drugs with the potential for dependence and misuse