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Consistent with human observations, H2O2 also promoted FOXO4 nuclear translocation in TM3 cells, along with an increase in senescence markers p53, phospho-p53, and p21, while reducing testosterone synthesis-related enzymes like CYP11A1 and CYP17A1
reported increased hepatic catalase levels following ozone therapy in a rat model of cecal perforation-induced sepsis, suggesting catalase as both a therapeutic effector and a biomarker of response (Erel et al., 2024)
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The latest 2022 review states: N-acetyl-L-cysteine (NAC) is a compound of increasing interest in the treatment of psychiatric disorders
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