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10.1016/j.ihj.2018.01.031 66 JamnongkanW.ThananR.TechasenA.NamwatN.LoilomeW.IntarawichianP.et al (2017)

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The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively