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Instead of waiting for treatment failure, structured response evaluations permit: Timely intervention for early non-responders Preservation of patient motivation and engagement More efficient resource allocation Insurance and access considerations for AOMs Access limitations pose substantial barriers for GLP-1 non-responders seeking alternative treatments

Bupropion is metabolized by CYP2B6, and the major inhibitors to worry about adding to it are the non-pram SSRIsthat is, all of them except escitalopram and citalopram

Pharmacokinetics GLP-1 (S) has a long half-life (~165 hours), allowing for once-weekly dosing

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