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ROS can damage cellular components such as lipids, proteins, and DNA, leading to cell death and loss of cardiac contractile function

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Mechanisms of action Reduces muscle damage and markers of inflammation and oxidative stress

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In our current study, inhibiting PFKFB3 with 3PO not only repressed glycolytic lactate production but also potently inhibited the activation of NLRP3 inflammasome in TGF-1 + IL-1-activated lung fibroblasts

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