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After subcutaneous administration at 5 g/day doses, some AVR antagonists demonstrated better inhibition of tumor growth in nude mice bearing various human cancers, with analog AVR-353 inducing stronger suppression than MIA-602 in lung, gastric, pancreatic, and colorectal cancers and AVR-352 in ovarian cancers and glioblastoma 73

These gaps highlight the need for future research to move beyond descriptive associations toward systematic dissection of ferroptosis initiation mechanisms, cell type-specific contributions, and clinical validation