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[19] United States [edit] In the United States, semaglutide is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes, [13] [14] and to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease

It has a more extensive research history including human clinical trials, though efficacy results were insufficient for continued pharmaceutical development

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Expression of GLP-1 receptor and CD26 in human thyroid C-cells: the association of thyroid C-cell tumorigenesis with incretin-based medicine