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In PROACTIVE, there was no difference in the composite primary outcome of death, non-fatal MI, non-fatal stroke, acute coronary syndrome, endovascular or surgical intervention in the coronary or lower extremity arteries, or amputation above the ankle after a median follow-up of just under 3 years (hazard ratio [HR]: 0.90

Rates of patients switching from AOM tirzepatide declined in the months following July 2025 and returned to near baseline levels by October, and growth in AOM tirzepatide prescribing rebounded after the initial decline

Participants understood and answered the items appropriately and noted that improvement in these symptoms would be meaningful

Take 2000 mcg of active vitamin B12 supplement (in the form of sublingual methylcobalamin) a day only after breakfast