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Here we describe the generation and preclinical evaluation of MEDI4166, a dual anti-PCSK9 antibody fused with a GLP-1 analogue agonist peptide, with the potential to provide significant benefit to T2D patients with high cardiovascular risk

Sound mechanistic evidence supports the need for further research on the GLP1-RAs/SGLT2is combinations ability to modify specific risk outcomes, such as cardiovascular risk and the progression of diabetic kidney disease

While bariatric surgery remains the most effective method for significant and sustained weight loss, its application is often limited by factors such as the availability of skilled surgeons, high costs, and the potential for postoperative complications 9

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