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Although immune dysfunction is clear in ME/CFS, further studies using defined cohorts, standardised assays, and new technologies are required to determine specific patterns (30)

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Research evidence The pivotal efficacy evidence comes from two identically designed Phase 3 randomized placebo-controlled trials run by Theratechnologies and reported by Julian Falutz and colleagues in the New England Journal of Medicine in 2007 (Falutz et al., NEJM 357:2359-2370)

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