A MMRM was used for the longitudinal endpoints including covariates: treatment arm, background therapy at baseline, age, sex, dopamine transporter-single-photon emission computed tomography (DaT-SPECT), contralateral putamen binding ratio at baseline, the visit (as a categorical factor), a group-by-visit interaction and the baseline endpoint
Obesity pharmacotherapy, such as GLP-1 receptor agonists, is often necessary for long-term weight management, and stopping these medications frequently results in weight regain
Diabetic retinopathy complications have been observed primarily with semaglutide, particularly with rapid glucose improvement in patients with pre-existing retinopathy, warranting ophthalmologic monitoring in high-risk individuals
The rats were provided with ad libitum access to food and water and were kept on a 12 h light/12 h dark cycle