long term tirzepatide side effects Unanticipated Adverse Events With Tirzepatide: Three Cases Underscoring the Importance of Postmarketing Monitoring 20 Possible Tirzepatide Side Effects

Insulin resistance is what happens when the cells in your muscles, fat, and liver don't respond well to insulin and can't use glucose (i.e., sugar) from your blood for energy, per the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Saxenda for weight management) Dulaglutide (Trulicity for diabetes only) Tirzepatide (Mounjaro) a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, with distinct pharmacology from pure GLP-1 agonists [2] [3] These medications work by mimicking the action of naturally occurring hormones that regulate blood glucose and appetite

Diabetologia 2018;61:28494.PubMed 2

You might have one or two symptoms for a long time before more obvious signs appear