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Ongoing research investigates its mechanisms and future applications for stress management in controlled laboratory settings

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335,336,337,338 As for non-malignant endothelial cells at regular oxygen concentrations, lactate activates hypoxia-inducible factor 1 (HIF-1) that enhance s basic fibroblast growth factor (bFGF) and vascular endothelial growth factor receptor 2 (VEGFR2) expression, which synergizes with lactate-induced VEGF secretion