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4.2.3 Effect of androgens/AR on mitophagy Mitophagy is a process whereby dysfunctional mitochondria are engulfed by autophagosomes and eventually cleared by lysosomal degradation after mitochondrial fission to maintain normal intracellular mitochondrial levels and metabolism

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The addition of glucagon receptor agonism provides potential additional mechanisms: Gluconeogenesis and glycogenolysis: Modulation of hepatic glucose production Thermogenesis: Research suggests glucagon may induce energy expenditure through effects on brown adipose tissue Lipolysis: Potential reduction in lipogenesis and increased fatty acid mobilization GI motility: Additional effects on gastric function Retatrutides structure includes modifications that provide stability from DPP-4 cleavage and a half-life of approximately six days, allowing for once-weekly administration

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