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This binding action facilitates a process known as "enterohepatic interruption." Normally, the body recycles bile acids from the intestines back to the liver, and unfortunately, any heavy metals mixed in the bile can be reabsorbed right alongside them, creating an endless loop of toxicity

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Many studies demonstrate Berberines positive effect on the GI tract

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice